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Shire plc  -  SHP   

Total Voting Rights

Released 12:00 02-Jan-2013

Total Voting Rights

Total Voting Rights

January 2, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in
accordance with DTR 5.6.1 of the FSA's Disclosure and Transparency Rules,
notifies the market of the following:

At close of business on December 31, 2012, the Company's issued ordinary share
capital comprised 558,914,764 ordinary shares of 5 pence each with voting
rights and a further 3,631,571 ordinary shares held in treasury.

Therefore the total number of voting rights in the Company is 558,914,764. This
is the figure which should be used by shareholders as the denominator for the
calculations by which they will determine if they are required to notify their
interest in, or a change to their interest in, the Company under the Financial
Services Authority's Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary


For further information please contact:

Investor Relations                                                             
                                                                               
Eric Rojas                              erojas@shire.com     +1 781 482 0999   
                                                                               
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157   

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of:

  * Behavioral Health and Gastro Intestinal conditions
   
  * Rare Diseases
   
  * Regenerative Medicine
   
as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

                                                                            
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     
                                                  
www.shire.com

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Total Voting Rights - RNS